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KMID : 0378019830260100123
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New Medical Journal
1983 Volume.26 No. 10 p.123 ~ p.128
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Natural Killer Cell Mediated Cytotoxicity in Children with Type A and Type B Hipatits
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양진/Yang, Jin
김종인/이준성/이재청/Kim, Jong In/Lee, Joon Sung/Lee, Jae Chung
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Abstract
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The pathogenesis of type A hepatitis is due to direct cytopathic role by hepatitis A virus, whereas the pathogenesis of type B hepatitis is most likely due to the interaction between the virus and the immune system of the individual host.
Especially, call-mediated immunity is well known to play a great cytopathic role in the pathogenesis of type B hepatitis.
To assessing immune competence in patients with hepatitis A and hepatitis B, natural killer cell mediated cytotoxicity (NKMC) against K562 cell has been studied in acute hepatitis A group (n=21), acute hepatitis B group (N=12) and age related healthy control group (n=11).
The results were as follows:
1. The mean NKMC in the acute hepatitis A group was 14.3±3.2 (effector cell to target call ratio; E : T=25: 1), 23.9±5.5 (E : T=50 : 1), that in the acute hepatitis B group was 13.7±3.9 (E : T=25:1),,22.1±2.9 (E : T=50: 1) and that in the control group was 15.5±3.2 (E: T=25: 1), 24.7±2.9 (E: T=50:1).
There was no difference in the mean NKMC between the acute hepatitis A group and the control group, and between the acute hepatitis B group and the control group.
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